Spaghetti night just got a spicy, cheesy upgrade with this irresistible Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce. It’s the perfect harmony of bold southern flavors and comforting Italian-inspired creaminess. The Cajun seasoning brings a smoky heat that complements the juicy chicken and rich sauce, while the spaghetti delivers that satisfying twirl-worthy base we all crave.

What makes this dish a true standout is how simple it is to pull together. You don’t need a culinary degree to whip up a pan of creamy, garlicky goodness that clings to every strand of pasta. It’s a one-pan wonder that balances spice, cream, and cheesy indulgence in every bite.

Why You’ll Love This Cajun Chicken Spaghetti

If you love meals that feel like a hug, this one is for you. The combination of garlic, heavy cream, and mozzarella melts into a velvety sauce that gently soothes the spice from the Cajun chicken. It’s weeknight-friendly but tastes like something you’d order from your favorite cozy bistro.

It’s also a great choice when you want a satisfying dinner without spending hours in the kitchen. Plus, it scales beautifully for guests or meal prep, reheats like a dream, and pairs well with a variety of sides.

What Kind of Pasta Works Best for Cajun Chicken Spaghetti?

Spaghetti is our go-to for this recipe because it lets that silky sauce cling to every strand. But if you prefer shorter pastas like penne or rotini, they work just as well. Just make sure to cook your pasta al dente so it holds up when tossed with the sauce.

And if you’re feeling adventurous, try it with fettuccine for an even richer feel or angel hair for a lighter twist. The beauty of this recipe is how adaptable it is to your pasta preferences.

Ingredients for the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

The ingredients in this recipe are all about building bold flavor while keeping things simple. You might already have most of these in your kitchen, and if not, they’re easy to find at any grocery store.

Chicken breast: The star protein, sliced thin so it cooks quickly and soaks up all that Cajun flavor.
Cajun seasoning: This brings the signature heat and smokiness to the dish. Adjust it to your spice preference.
Spaghetti: A classic base that soaks up the creamy sauce beautifully.
Garlic: Essential for infusing the sauce with a rich, savory aroma.
Heavy cream: This gives the sauce its luxurious, velvety texture.
Mozzarella cheese: Melts into the cream to create a stretchy, cheesy finish.
Parmesan cheese: Adds a salty, nutty depth to balance the creaminess.
Butter: Helps sear the chicken and adds richness to the sauce.
Olive oil: Used for cooking the chicken and building the sauce base.
Salt and pepper: Basic seasonings to bring everything into balance.
Fresh parsley (optional): Adds a pop of color and freshness at the end.

How To Make the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

Step 1: Season and Sear the Chicken

Slice your chicken breasts into thin strips. Toss them with Cajun seasoning, salt, and pepper. In a large skillet over medium heat, add olive oil and sear the chicken until it’s golden and fully cooked. Set aside.

Step 2: Cook the Spaghetti

While the chicken is cooking, boil a pot of salted water and cook the spaghetti until al dente. Drain and set aside, reserving about 1/2 cup of pasta water.

Step 3: Build the Sauce Base

In the same skillet, reduce heat and add butter. Once melted, sauté minced garlic until fragrant, about 30 seconds. Pour in the heavy cream and bring to a gentle simmer.

Step 4: Add the Cheese

Stir in the mozzarella and Parmesan cheeses until the sauce becomes thick and creamy. Add a splash of reserved pasta water if the sauce feels too thick.

Step 5: Combine and Finish

Return the cooked chicken to the pan, then toss in the cooked spaghetti. Stir everything together so the pasta is evenly coated. Taste and adjust seasoning if needed. Garnish with chopped parsley if you like, and serve immediately.

Serving and Storing This Creamy Cajun Chicken Spaghetti

This dish is hearty enough to stand on its own, but it’s also incredibly versatile. Whether you’re cooking for two or feeding a crowd, it serves about 4 people generously. The creamy garlic mozzarella sauce coats every strand, making it rich and comforting in every bite.

For storing, let the spaghetti cool to room temperature before transferring it to an airtight container. It keeps well in the fridge for up to 3 days. When reheating, add a splash of milk or cream to revive the sauce’s silky texture. You can reheat it in the microwave or over low heat on the stove.

What to Serve With Cajun Chicken Spaghetti?

Garlic Bread

A crispy slice of garlic bread is perfect for scooping up any extra sauce left on your plate.

Simple Green Salad

Balance out the richness with a fresh salad of greens, cucumbers, and a light vinaigrette.

Roasted Broccoli

Roasted or steamed broccoli adds a healthy crunch and holds up well to the creamy sauce.

Grilled Asparagus

Its earthy flavor pairs nicely with the Cajun spices and adds a bright note.

Corn on the Cob

A buttery ear of corn is a playful Southern-style companion to this creamy pasta.

Sautéed Spinach

Quickly sautéed in olive oil and garlic, spinach complements the richness without overpowering it.

Caprese Salad

Tomato, mozzarella, and basil bring an Italian freshness that works beautifully with this dish.

Iced Tea or Lemonade

For a casual dinner, nothing beats sipping on a chilled glass of iced tea or lemonade alongside the heat of Cajun spice.

Want More Chicken Pasta Ideas?

If this creamy, spicy pasta hit the spot, you’ll love exploring more pasta favorites that bring the comfort and flavor in every forkful:

• Creamy Tomato Spinach Pasta for a veggie-rich twist with a tangy bite.
• Creamy Cajun Sausage Pasta for a meaty variation with smoky sausage flavor.
• One-Pot Creamy Sausage Rigatoni if you love easy cleanup and bold taste.
• Tuscan Chicken Pasta with sun-dried tomatoes and a creamy garlic sauce.
• Garlic Butter Chicken Balls with Creamy Parmesan Pasta for a fun spin with juicy bites of chicken.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go bold with the Cajun spice or tone it down a little? Add mushrooms or bell peppers? I’m always curious to hear how you make it your own.

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Conclusion

Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce is one of those meals that makes everyone at the table happy. It’s rich without being too heavy, spicy without overwhelming, and simple enough to make on a weeknight. If you’re looking to shake up your dinner routine with something bold, creamy, and totally comforting, this one absolutely belongs in your rotation.