This Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is a flavor-packed twist on classic comfort food. It brings together rich Cajun spice, juicy ground beef, and a velvety sauce made from not one, not two, but three cheeses for an ultra-indulgent finish. Whether you’re feeding your family or entertaining friends, this pasta dish will disappear faster than you can say “seconds.”

The secret to this creamy Cajun spaghetti is layering flavor. The beef is seared with Cajun seasoning to give it that bold, smoky heat. Then it simmers in a sauce that combines cream cheese, mozzarella, and parmesan until everything melts into creamy perfection. It clings to every strand of spaghetti, delivering a luscious bite with just the right amount of kick.

Why You’ll Love This Creamy Cajun Beef Spaghetti

This dish is weeknight-friendly but dinner party-worthy. It’s hearty, fast, and full of big flavor. The three-cheese sauce adds richness without being heavy, while the Cajun seasoning wakes everything up with a touch of spice. It’s the kind of pasta that makes you look forward to leftovers—if there are any!

What Kind of Cajun Seasoning Should I Use?

The best Cajun seasoning for this recipe is one with a good balance of paprika, garlic powder, onion powder, oregano, and cayenne. You can use a store-bought blend like Slap Ya Mama or Tony Chachere’s, or mix your own if you want to control the heat. Just make sure it has depth—you want it to do more than just bring the burn.

Ingredients for the Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

This ingredient list is simple but strategic. Every element plays a role in building flavor and texture, from the bold Cajun spice to the creamy cheese blend. Here’s what you’ll need to make this spaghetti shine:

Ground beef
Spaghetti
Cajun seasoning
Garlic cloves
Yellow onion
Cream cheese
Mozzarella cheese
Parmesan cheese
Heavy cream
Butter
Olive oil
Salt and pepper
Fresh parsley (optional)

Each cheese plays a part—cream cheese makes the sauce silky, mozzarella adds stretch and richness, and parmesan brings that sharp, nutty edge. The ground beef soaks up the Cajun seasoning and provides that hearty, satisfying bite, while garlic and onion deepen the savory base. A splash of heavy cream ties everything together.

How To Make the Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

Step 1: Boil the Pasta

Bring a large pot of salted water to a boil and cook the spaghetti until just al dente. Reserve 1/2 cup of pasta water, then drain and set aside.

Step 2: Cook the Beef

In a large skillet, heat olive oil and butter over medium-high heat. Add the ground beef, breaking it apart as it cooks. Season with Cajun seasoning, salt, and pepper, and cook until browned and fully cooked through.

Step 3: Sauté the Aromatics

Add the finely chopped onion and minced garlic to the pan. Cook until the onions are translucent and fragrant, about 3 minutes.

Step 4: Make the Cheese Sauce

Lower the heat and stir in the cream cheese until melted. Pour in the heavy cream, then gradually add the mozzarella and parmesan, stirring constantly until smooth. If the sauce is too thick, stir in a bit of the reserved pasta water.

Step 5: Combine Pasta and Sauce

Add the cooked spaghetti into the skillet with the sauce and toss well to coat every strand. Let it simmer for 2-3 minutes so the flavors meld.

Step 6: Garnish and Serve

Serve hot, topped with chopped fresh parsley for a pop of color and freshness if desired. Enjoy!

How to Serve and Store Creamy Cajun Beef Spaghetti

This Creamy Cajun Beef Spaghetti feeds about four people generously, making it perfect for a family dinner or easy entertaining. Serve it hot from the skillet, with a side of crusty bread or a simple green salad to soak up that luscious three-cheese sauce.

To store leftovers, let the spaghetti cool completely, then transfer it to an airtight container. It will keep in the refrigerator for up to 4 days. When reheating, add a splash of milk or cream and stir gently to bring the sauce back to life without breaking.

For longer storage, this pasta also freezes well. Place it in a freezer-safe container and freeze for up to 2 months. Thaw in the fridge overnight and reheat on the stovetop over low heat.

What to Serve With Creamy Cajun Beef Spaghetti?

H3: Garlic Bread

Buttery garlic bread is a natural companion to this spicy, creamy pasta. It adds crunch and is perfect for wiping your plate clean.

H3: Simple Arugula Salad

A light arugula salad with lemon vinaigrette adds a peppery freshness that contrasts beautifully with the richness of the sauce.

H3: Roasted Brussels Sprouts

Their earthy crispiness makes a great counterpoint to the creamy texture of the pasta.

H3: Cornbread Muffins

Add a southern twist by serving sweet or savory cornbread muffins on the side.

H3: Creamy Cucumber Salad

Cool things down with a chilled cucumber salad tossed in Greek yogurt or sour cream dressing.

H3: Parmesan Roasted Broccoli

A sprinkle of parmesan on roasted broccoli keeps the flavors in sync while offering a crunchy veggie side.

H3: Fried Green Tomatoes

Golden and tangy, these southern classics make for a crispy complement to the dish.

H3: Deviled Eggs

For potluck-style meals, deviled eggs offer a creamy and mild bite that balances the spice in the spaghetti.

Want More Pasta Ideas with a Kick?

If this Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce brought some excitement to your dinner table, you’ll love exploring more bold and comforting dishes like these:

Creamy Cajun Sausage Pasta for a smoky one-pot wonder.
Creamy Tomato Spinach Pasta when you’re craving something cozy and vibrant.
One-Pot Creamy Sausage Rigatoni if you love rich sauces with fewer dishes.
Creamy Cottage Cheese Pasta Sauce for a protein-packed twist.
Garlic Butter Chicken Balls with Creamy Parmesan Pasta for a next-level cheesy meal.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can revisit it any time you need a fast and flavorful pasta fix.

Let me know in the comments how yours turned out. Did you dial up the spice or stick with mild? Did you sneak in any extra veggies?

I always love seeing how others add their spin to the recipes. If you have questions or want ideas for tweaks, feel free to ask.

Explore more crave-worthy meals and comfort food classics on Janet Dishes on Pinterest and find inspiration for every day of the week.
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Conclusion

Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is the ultimate mash-up of spicy, cheesy, and comforting. With its silky sauce, bold Cajun flavor, and meaty bite, this dish turns a weeknight into a mini celebration. And best of all, it’s easy enough for any home cook to master. So go ahead, treat yourself and your table to something a little extra tonight.