If you crave comforting pasta dinners with a bold twist, Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce is going to be your new obsession. This dish strikes the perfect balance between creamy indulgence and Cajun spice. The juicy chicken is seared to golden perfection, then coated in a rich sauce that hugs every swirl of rotini.

It’s the kind of weeknight dinner that feels like a treat but comes together with simple pantry staples. What makes it really shine is the garlicky mozzarella sauce that melts beautifully over the seasoned chicken, wrapping the whole dish in a velvety, cheesy cloak. It’s hearty, crave-worthy, and the kind of meal that gets scraped clean every single time.

Why You’ll Love This Creamy Cajun Chicken Rotini

This recipe delivers bold flavor with minimal effort. It packs heat from Cajun seasoning, creamy richness from the mozzarella and cream, and a cozy depth from sautéed garlic. Whether you’re cooking for family, friends, or just yourself, it feels special but doesn’t take all night. You get that restaurant-level satisfaction without stepping outside your kitchen.

What Kind of Rotini Should I Use?

Rotini holds creamy sauces like a champ. The spirals catch every bit of that mozzarella-garlic blend so you don’t miss a drop. You can use traditional semolina rotini or whole wheat for extra fiber. Even gluten-free options work beautifully if needed. The shape is what matters most—just make sure it’s pasta that can cradle sauce in every groove.

Ingredients for the Creamy Cajun Chicken Rotini

To make this dish sing with bold and creamy flavor, every ingredient plays an essential role. The Cajun spices bring warmth, the garlic builds aroma, and the mozzarella turns everything into silky comfort.

Rotini pasta
Chicken breast
Cajun seasoning
Garlic cloves
Butter
Heavy cream
Mozzarella cheese
Salt
Black pepper
Olive oil

How To Make the Creamy Cajun Chicken Rotini

Step 1: Season and Sear the Chicken

Slice chicken breasts into thin strips. Season generously with Cajun spice, salt, and pepper. Heat olive oil in a skillet and sear the chicken until golden and cooked through. Set aside.

Step 2: Boil the Pasta

While the chicken cooks, boil rotini pasta in salted water until al dente. Drain and reserve a bit of the pasta water.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, melt butter and add minced garlic. Sauté until fragrant. Pour in heavy cream, stirring gently until heated through. Slowly add mozzarella, stirring until melted and smooth. Use reserved pasta water if the sauce needs thinning.

Step 4: Bring It All Together

Return the chicken to the skillet and stir in the cooked pasta. Toss to coat everything in that creamy sauce. Let it simmer for 2-3 minutes for flavors to meld. Serve warm and garnish with extra cheese or parsley if desired.

How to Serve and Store Creamy Cajun Chicken Rotini

This pasta dish is best served immediately while the sauce is still silky and warm. It feeds 4 hungry adults comfortably, or 5 to 6 smaller portions. If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop or in the microwave with a splash of cream or milk to bring back its original creaminess.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread

Crispy, buttery garlic bread helps mop up any leftover sauce and adds a satisfying crunch.

Simple Green Salad

A fresh mix of greens with a tangy vinaigrette balances the richness of the pasta.

Roasted Asparagus

Lightly roasted asparagus offers a clean, earthy side to contrast the creamy sauce. Try this roasted asparagus recipe.

Grilled Corn on the Cob

Grilled corn adds sweetness and a bit of smoky flavor that pairs well with Cajun spices.

Lemon Butter Broccoli

The citrusy punch from lemon brightens up every bite of this hearty dish.

Tomato Cucumber Salad

A cool, crisp salad helps refresh the palate after each spicy, creamy forkful.

Garlic Parmesan Roasted Potatoes

If you want something even heartier, these roasted potatoes are a flavor-packed match.

Herby Chicken Meatball Bowl

If you’re feeding a crowd, serve this alongside a herby chicken meatball bowl for a protein-packed dinner spread.

Want More Chicken Pasta Ideas?

If you love this Creamy Cajun Chicken Rotini, you’ll probably enjoy these other comforting meals:

Creamy Tomato Spinach Pasta for a vegetarian-friendly twist.
One-Pot Creamy Sausage Rigatoni when you’re short on time and need one pan.
Creamy Cajun Sausage Pasta for a spicier, smoky take on this creamy theme.
Garlic Butter Chicken Balls with Creamy Parmesan Pasta if you’re craving something playful and savory.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go heavy on the Cajun spice or ease it back? Did you try a different cheese combo?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

Explore beautifully curated health-boosting dinners on Janet Dishes on Pinterest and discover your new go-to for feeling great!

Conclusion

Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce brings together everything you want in a comfort meal: bold flavor, silky texture, and effortless elegance. Whether it’s a Tuesday night or a cozy dinner with guests, this pasta checks all the boxes.