When you’re craving something cozy but with a little heat, Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce hits all the right notes. The rotini noodles hug the rich, cheesy Alfredo sauce in every bite, and the Cajun seasoning infuses the chicken with a bold, peppery kick that keeps things interesting. It’s the kind of dinner that feels like comfort food but still has a gourmet twist.

Whether you’re cooking for a weeknight family dinner or looking to impress friends with a satisfying pasta dish, this recipe delivers. It’s indulgent but balanced, with juicy chicken, gooey mozzarella, and that signature Cajun flavor mingling in a creamy, velvety sauce. One skillet, one pot of pasta, and you’re on your way to a meal that disappears fast.

Why You’ll Love This Creamy Cajun Chicken Rotini

This dish blends spicy, creamy, and cheesy in a way that keeps your fork going back for more. The Cajun seasoning adds a deep warmth, but the mozzarella Alfredo sauce smooths it out into a luscious experience that even spice-sensitive eaters can enjoy. Plus, rotini is perfect for soaking up sauce, ensuring every bite is full of flavor.

If you’re tired of bland pasta dinners, this one will wake up your weeknight routine. It’s filling, layered in flavor, and comes together quickly without sacrificing taste.

What Kind of Cajun Seasoning Should I Use?

Not all Cajun seasonings are created equal. Some are saltier, while others focus more on heat or herbaceous undertones. You can use a store-bought blend if you’re in a pinch, but if you make your own, you get full control over the spice level. Look for one that includes paprika, garlic powder, onion powder, thyme, and a bit of cayenne for the perfect blend. If your seasoning is heavy on salt, be sure to adjust the rest of your recipe so it doesn’t become overly salty. Homemade Cajun spice blends allow you to keep it flavorful without going overboard on the heat.

Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

To create this irresistible pasta, you’ll need a handful of simple ingredients that come together in the most delicious way. Each one plays a role in building flavor and richness, so don’t skip anything if you want the full experience.

Rotini pasta
Chicken breasts
Cajun seasoning
Olive oil
Garlic
Heavy cream
Mozzarella cheese
Parmesan cheese
Butter
Salt and black pepper
Fresh parsley

The rotini pasta is perfect for catching all that creamy sauce in its spirals. Chicken breasts add a lean protein that pairs beautifully with the Cajun seasoning’s bold flavor. Cajun seasoning is the soul of the dish, bringing warmth and spice. A little olive oil helps sear the chicken to a golden brown, while garlic adds that irresistible depth.

Heavy cream forms the base of your Alfredo sauce, and when paired with mozzarella cheese and Parmesan, it becomes luxuriously creamy. A touch of butter adds silkiness, and a sprinkle of salt and black pepper keeps the flavors balanced. Finish with fresh parsley for a bright, herbaceous contrast.

Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce 2

How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the rotini according to the package instructions until al dente. Drain and set aside.

Step 2: Season and Cook the Chicken

While the pasta cooks, slice the chicken breasts into bite-sized pieces. Toss them in Cajun seasoning until fully coated. In a large skillet over medium heat, warm olive oil and cook the chicken until browned and cooked through. Remove and set aside.

Step 3: Make the Alfredo Base

In the same skillet, melt the butter and add minced garlic. Sauté for about 30 seconds until fragrant. Pour in the heavy cream and bring to a gentle simmer. Stir occasionally until the cream slightly thickens.

Step 4: Add Cheese and Blend

Lower the heat and gradually stir in the mozzarella and Parmesan cheese. Continue stirring until the cheeses melt into the sauce and the mixture is smooth and creamy.

Step 5: Combine Everything

Return the cooked chicken to the skillet and mix until coated in sauce. Add the drained rotini and toss everything together, making sure the pasta is fully covered in the creamy Alfredo.

Step 6: Garnish and Serve

Sprinkle freshly chopped parsley on top and serve immediately while warm and gooey. Enjoy that melty, spicy, creamy goodness!

How to Serve and Store Creamy Cajun Chicken Rotini

This recipe generously feeds about 4 to 6 people, making it a fantastic family-style dinner or something special to prep ahead for the week. The creamy texture holds up surprisingly well, even as leftovers.

To serve, scoop the warm rotini into shallow bowls to showcase that silky Alfredo sauce clinging to the spirals. A sprinkle of chopped parsley or extra Parmesan adds an inviting finish. If you’re entertaining, serve it in a large dish and let everyone help themselves.

If you have leftovers, transfer them to an airtight container once cooled. Store in the fridge for up to 3 days. When reheating, add a splash of cream or milk to loosen the sauce and bring back that creamy consistency.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread with Herb Butter

A warm, crusty garlic bread is ideal for soaking up any extra sauce on the plate. The buttery herb flavor complements the Cajun spices beautifully.

Simple Garden Salad

A crisp garden salad with romaine, cherry tomatoes, cucumber, and a light vinaigrette balances the richness of the pasta.

Roasted Broccoli

Oven-roasted broccoli with crispy edges adds a fresh, slightly bitter contrast that pairs well with the creamy sauce.

Southern Cornbread Poppers

For something fun and Southern-inspired, these little bites are a golden and spicy companion to your creamy pasta.

Grilled Asparagus

A bundle of charred asparagus adds a smoky note and some welcomed greens to your plate.

Baked Chicken Ricotta Meatballs

Make it a double chicken night by pairing this pasta with cheesy, baked meatballs. They match the richness of the Alfredo sauce in all the right ways.

Classic Caprese Salad

Mozzarella, tomatoes, and basil bring a cool, bright freshness that contrasts the heat and creaminess of the pasta.

Roasted Zucchini and Squash

This colorful medley brings a mellow sweetness that won’t overpower the dish, making it a perfect match for spiced pasta.

Want More Pasta Ideas with a Kick?

If this Creamy Cajun Chicken Rotini left you craving more bold and creamy pasta dishes, there’s a lot more to explore. Here are some other favorites that deliver flavor in every bite:

Creamy Cajun Sausage Pasta is another spicy and creamy combination, but with the smoky flavor of sausage.
Creamy Tomato Spinach Pasta for a tangy and vibrant twist on weeknight pasta.
One Pot Creamy Sausage Rigatoni if you want minimal cleanup and major comfort.
Tuscan Chicken Pasta for something a bit more earthy and herby but still indulgent.

Each of these recipes brings a new dimension to your pasta nights, whether you want more spice, more veggies, or more cheesy goodness.

Save This Recipe For Later

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And if you make this dish, I’d love to hear about it in the comments. Did you crank up the spice or add mushrooms or bell peppers? Did you use a different pasta shape?

Let’s share ideas and keep making our kitchens the most delicious place to be.

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Conclusion

Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is a dish that delivers everything you want in a comfort meal: heat, creaminess, cheesy goodness, and satisfaction in every forkful. Whether you’re serving a family meal or impressing friends, it’s a recipe worth keeping on repeat.

Don’t forget to check out more flavorful dinners at Janet Dishes—you just might find your next obsession.