Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

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Rich, spicy, and irresistibly creamy, this Cajun chicken spaghetti will make you wonder why you ever settled for plain Alfredo. It’s a flavor-packed meal that merges the bold punch of Cajun spices with the smoothness of a garlic mozzarella cheese sauce. Perfect for busy weeknights yet special enough for a date night at home, this recipe brings comfort with a kick.

Each bite offers tender spaghetti tangled with juicy seared chicken, coated in a velvety sauce that’s cheesy, garlicky, and a touch smoky. The Cajun seasoning brings depth and warmth, while the mozzarella adds that stretchy, creamy goodness we all crave. It’s an easy dinner that feels a little indulgent—and totally worth it.

Why You’ll Love This Creamy Cajun Chicken Spaghetti

This pasta dish has everything: protein, carbs, cream, and spice. It comes together quickly and fills the kitchen with an irresistible aroma that guarantees you won’t need to call anyone twice for dinner. You get the richness of mozzarella without the heaviness of cream-based sauces, and it’s a perfect way to switch up your usual pasta routine.

What Kind of Pasta Should I Use?

Spaghetti works beautifully for this recipe because it captures the sauce without being too heavy. But you can easily swap it for fettuccine, linguine, or even penne if you prefer a bite-sized noodle that catches the sauce in every curve. The main goal is to choose a pasta that doesn’t overpower the Cajun-spiced chicken and lets the creamy garlic sauce shine.

Ingredients for the Creamy Cajun Chicken Spaghetti

To make this dish as rich and flavorful as possible, each ingredient plays a unique role. The Cajun seasoning infuses the chicken with spice and smokiness, while the mozzarella melts into the sauce to create that dreamy, stringy texture. Use fresh garlic and good-quality pasta for the best results.

• Chicken breast
• Spaghetti
• Cajun seasoning
• Garlic cloves
• Olive oil
• Butter
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Salt
• Black pepper
• Parsley (for garnish)

How To Make the Creamy Cajun Chicken Spaghetti

Step 1: Season and Cook the Chicken

Start by slicing your chicken breast into strips. Toss the chicken in Cajun seasoning and a pinch of salt and pepper. Heat olive oil in a skillet over medium-high heat and cook the chicken until browned and cooked through. Set aside.

Step 2: Boil the Pasta

In a large pot, cook spaghetti according to the package instructions until al dente. Reserve 1/2 cup of the pasta water before draining.

Step 3: Create the Garlic Mozzarella Sauce

In the same skillet used for the chicken, melt butter and add minced garlic. Sauté until fragrant. Pour in the heavy cream and let it simmer for a few minutes. Stir in the mozzarella and Parmesan until melted and smooth.

Step 4: Combine Everything

Add the cooked spaghetti to the sauce, tossing to coat. If the sauce is too thick, loosen it with a splash of the reserved pasta water. Return the chicken to the pan and mix well.

Step 5: Serve and Garnish

Plate the pasta and top with chopped parsley. Serve hot and enjoy the layers of flavor in every forkful.

How to Serve and Store Creamy Cajun Chicken Spaghetti

This dish is best served hot and fresh, right after the sauce has coated every strand of spaghetti and the chicken is still juicy. A sprinkle of extra Parmesan and chopped parsley adds that final touch of flavor and presentation. If you’re planning ahead or end up with leftovers, store it in an airtight container in the fridge for up to 3 days. Reheat gently on the stovetop with a splash of cream or milk to loosen the sauce.

This recipe feeds about 4 people generously, especially if paired with a side dish or salad. It’s perfect for family dinners or small gatherings when you want something hearty and satisfying.

What to Serve With Creamy Cajun Chicken Spaghetti?

Garlic Bread

Warm, crusty garlic bread is a natural match. It soaks up the sauce beautifully.

Classic Caesar Salad

The crisp Romaine and tangy dressing help cut through the richness of the pasta.

Roasted Broccoli

A simple roasted vegetable side brings a bit of crunch and earthy contrast.

Sweet Corn on the Cob

The sweetness of corn adds a balance to the spiced chicken and creamy sauce.

Sauteed Green Beans

These provide a fresh, snappy bite to round out the meal.

Southern Fried Okra

If you’re leaning into the Southern-style theme, fried okra offers a crispy, fun texture.

Sparkling Lemon Water

A refreshing drink like sparkling water with lemon helps cleanse the palate.

Fresh Tomato Cucumber Salad

Something light and acidic pairs perfectly to lighten the meal and add freshness.

Want More Pasta Dinner Ideas?

If this creamy Cajun chicken spaghetti has you hooked on bold and creamy pasta dishes, you might want to add these other weeknight winners to your rotation:

• Creamy Tomato Spinach Pasta is a great option when you want something quick with a fresh, veggie-forward twist.
• One-Pot Creamy Sausage Rigatoni brings together sausage and pasta with minimal cleanup.
• Creamy Cajun Sausage Pasta for another hit of Cajun flavor, but with sausage instead of chicken.
• Garlic Butter Chicken Balls with Parmesan Pasta if you’re after a garlic-forward, hearty dish.
• Creamy Mushroom Ravioli when you’re in the mood for a vegetarian creamy pasta.

Save This Recipe For Later

📌 Save this recipe to your Pinterest board for dinner ideas so it’s just a click away when you need a cozy, satisfying meal.

Have you made your own spin on this? Maybe added sun-dried tomatoes or a splash of white wine to the sauce? Share your version in the comments—I’d love to hear what worked for you.

Explore beautifully curated health-boosting drinks, cozy meals, and more comfort food inspiration on Janet Dishes on Pinterest and discover your new go-to for flavorful, feel-good cooking.

Conclusion

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is one of those recipes that hits all the marks: creamy, spicy, comforting, and quick to prepare. It’s perfect for weeknight dinners but also good enough to serve to guests. Whether you’re new to Cajun cooking or just love a creamy pasta dish, this one deserves a spot in your dinner rotation.

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