There are comfort meals, and then there are unforgettable comfort meals. This creamy Cajun chicken twisted pasta delivers both heat and indulgence, all wrapped in cheesy, rich Alfredo goodness. Twisted pasta catches every drop of sauce, while juicy Cajun-seasoned chicken brings bold flavor to each bite.

With its layers of creamy mozzarella Alfredo and a touch of Cajun spice, this recipe feels fancy enough for weekend hosting but is easy enough to throw together on a weeknight. It’s a pasta dish that doesn’t hold back on flavor or texture—and once you make it, you’ll be craving it regularly.

Why You’ll Love This Creamy Cajun Chicken Twisted Pasta

The magic of this dish lies in its balance of creamy and spicy. The Cajun seasoning creates depth without overwhelming heat, while the mozzarella Alfredo sauce smooths everything into a velvety finish. It comes together with simple ingredients you probably already have and gives you restaurant-quality taste in one pan.

This pasta is also endlessly adaptable. You can add bell peppers, spinach, or mushrooms to sneak in some veggies, or swap the chicken for shrimp if you want a seafood twist.

What Kind of Pasta Works Best for This?

Twisted pasta, like rotini or fusilli, works beautifully here because its shape grabs onto the sauce and locks in flavor. However, penne or cavatappi also do the job well. The real key is using a pasta that has grooves or twists—something with texture to carry all that creamy Cajun goodness straight to your fork.

Ingredients for the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

This recipe blends spice and cream into a deeply satisfying dish. Each ingredient has its own role in creating the balance between smoky heat and cheesy comfort.

Twisted pasta
Chicken breasts
Cajun seasoning
Olive oil
Butter
Garlic
Heavy cream
Mozzarella cheese
Parmesan cheese
Salt
Black pepper

Twisted pasta gives this dish its hearty base and holds onto the creamy sauce. Chicken breasts are sliced thin and cooked with Cajun seasoning for a smoky, peppery flavor. Olive oil and butter are used to sear the chicken and cook the garlic for added richness. Heavy cream brings the Alfredo together, while mozzarella gives that signature stretch and melt. A bit of Parmesan adds depth, and salt and black pepper round everything out perfectly.

Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo 2

How To Make the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Step 1: Season and Sear the Chicken

Slice chicken breasts into thin strips and season them generously with Cajun seasoning. In a large skillet over medium heat, add olive oil and sear the chicken until golden brown on both sides and cooked through. Remove and set aside.

Step 2: Cook the Pasta

While the chicken cooks, boil your twisted pasta according to package directions. Drain and set aside, reserving a cup of pasta water.

Step 3: Make the Mozzarella Alfredo Sauce

In the same skillet, melt butter and add minced garlic. Sauté until fragrant. Pour in heavy cream and simmer for 2-3 minutes. Stir in shredded mozzarella and grated Parmesan cheese. Continue stirring until the sauce becomes smooth and creamy.

Step 4: Bring It All Together

Add the cooked pasta into the sauce and toss to coat evenly. Use the reserved pasta water as needed to loosen the sauce. Add the cooked Cajun chicken back into the skillet and stir to combine.

Step 5: Serve Hot

Serve immediately while hot and gooey. Add extra Parmesan on top and a sprinkle of Cajun seasoning if you love extra heat.

How to Serve and Store Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

This creamy Cajun chicken pasta is best served fresh and piping hot, right off the stove. That’s when the mozzarella Alfredo sauce is at its most luscious and the chicken is at peak juiciness. This recipe yields about 4 to 5 hearty servings, making it perfect for family dinners or small gatherings.

If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. When reheating, add a splash of milk or cream to help revive the sauce and stir gently over low heat. While it can be frozen, the creamy texture may change slightly after thawing.

What to Serve With Creamy Cajun Chicken Twisted Pasta?

Garlic Bread

A golden, buttery slice of garlic bread is perfect for scooping up every drop of that mozzarella Alfredo sauce.

Simple Green Salad

Crisp romaine or mixed greens with a tangy vinaigrette helps cut through the richness of the dish.

Roasted Broccoli

A tray of oven-roasted broccoli adds texture and a slightly bitter contrast that balances the creamy pasta.

Grilled Asparagus

Tender-crisp grilled asparagus complements the smoky Cajun spice and adds color to your plate.

Creamed Spinach

If you’re in the mood for extra comfort, a creamy spinach side harmonizes with the Alfredo base.

Cornbread Muffins

Sweet and savory cornbread muffins pair surprisingly well, especially if you enjoy Southern-inspired combinations.

Balsamic Glazed Carrots

Roasted carrots with a balsamic glaze bring a hint of sweetness and acidity that works with the bold Cajun flavors.

Lemon Butter Green Beans

Zesty green beans cooked in lemon butter add brightness and freshness to the overall meal.

Want More Pasta Ideas with a Twist?

If you love the bold comfort of this creamy Cajun chicken twisted pasta, here are some other delicious pasta dishes you might want to try next:

• Creamy Tomato Spinach Pasta for a tangy, veggie-packed experience.
• One Pot Creamy Sausage Rigatoni when you crave a meaty, one-pan weeknight dinner.
• Creamy Cottage Cheese Pasta Sauce Recipe for a high-protein creamy sauce alternative.
• Tuscan Chicken Pasta with sun-dried tomatoes and a dreamy Parmesan cream sauce.
• Creamy Cajun Sausage Pasta to double down on smoky Cajun spice in pasta form.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can revisit it whenever you’re craving something creamy, spicy, and soul-satisfying.

And let me know in the comments how it turned out. Did you keep it classic or add your own twist? I’d love to hear how you made it yours.

Explore beautifully curated comfort food recipes on Janet Dishes on Pinterest and discover your new go-to for weeknight inspiration.

Conclusion

Creamy Cajun chicken twisted pasta with mozzarella Alfredo is one of those meals that feels like a hug in a bowl. The heat from the Cajun spice, the richness of the cheese, and the hearty pasta make it a knockout combo. Whether you’re feeding a crowd or cooking for yourself, it’s a dish that delivers every time. Make it once, and it’ll quickly earn a spot in your regular dinner rotation.