Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

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When comfort food meets bold flavor, you get something truly irresistible like Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream. This dish is a symphony of creamy richness, tender pasta, and fiery Cajun-spiced chicken, all swirled together in a velvety garlic parmesan sauce that clings to every bite.

It has everything you could want in a weeknight meal: quick prep, easy cleanup, and layers of savory, cheesy flavor that feel like a warm hug. The cajun seasoning brings just the right kick to balance the luscious cream sauce, and the melted cheese rounds it out with gooey goodness. Whether you’re cooking for your family or hosting a casual dinner, this is a dish that leaves no leftovers behind.

Why You’ll Love This Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

You’ll adore how indulgent and satisfying this meal is without requiring complex ingredients or advanced cooking skills. It delivers restaurant-level flavor from your own stove in under 45 minutes. The Cajun spice adds a warm heat that contrasts beautifully with the buttery, garlicky parmesan sauce, and the combination of textures—crispy edges on the chicken, soft pasta, creamy sauce—keeps each bite exciting. Plus, it reheats like a dream.

What Kind of Cajun Chicken Should I Use?

Boneless skinless chicken breasts work perfectly for this recipe, but thighs can be a juicier alternative if preferred. The real key is coating them generously with Cajun seasoning before searing to a golden brown. You can also use pre-cooked grilled chicken or rotisserie in a pinch, though fresh-cooked delivers the best flavor. If you’re after even more depth, marinate the chicken with Cajun seasoning and a splash of olive oil for 30 minutes before cooking.

Ingredients for the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

This recipe leans on pantry staples and bold spices to bring it to life, but each ingredient plays a special role in the final flavor. Here’s what you need:

• Penne pasta
• Chicken breast
• Cajun seasoning
• Olive oil
• Garlic cloves
• Heavy cream
• Parmesan cheese
• Mozzarella cheese
• Butter
• Salt
• Black pepper
• Fresh parsley

How To Make the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Step 1: Sear the Cajun Chicken

Season the chicken breasts generously with Cajun seasoning on both sides. Heat olive oil in a skillet over medium-high heat. Sear the chicken until golden and cooked through, about 5–6 minutes per side. Remove and let rest before slicing.

Step 2: Boil the Pasta

Bring a large pot of salted water to a boil and cook the penne pasta until al dente. Drain and set aside.

Step 3: Create the Garlic Parmesan Cream Sauce

In the same skillet, reduce the heat and add butter. Stir in minced garlic and let it cook until fragrant, around 1 minute. Pour in the heavy cream and bring to a simmer. Slowly whisk in the parmesan and mozzarella until melted and smooth.

Step 4: Combine Everything

Add the cooked pasta to the sauce, tossing to coat well. Slice the Cajun chicken and layer it over the pasta. Let it simmer together for a minute or two so the flavors meld.

Step 5: Garnish and Serve

Sprinkle with fresh parsley and a touch more parmesan before serving hot.

Serving and Storing Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

This recipe feeds about four hearty portions, making it a reliable dinner choice for families or for meal prepping throughout the week. Serve it piping hot straight from the skillet, or let it cool and store in an airtight container in the fridge for up to 4 days. Reheat on the stove with a splash of cream or milk to loosen the sauce, or microwave in short intervals.

The sauce may thicken slightly as it sits, but a quick stir brings it right back to its creamy glory. It’s not freezer-friendly due to the dairy content, so stick to enjoying it fresh or from the fridge.

What to Serve With Cheesy Penne and Cajun Chicken?

Garlic Bread

Buttery garlic bread adds that irresistible crunch and is perfect for mopping up any extra cream sauce.

Classic Caprese Salad

A fresh Caprese salad like the one from this recipe helps cut the richness and brings brightness to the plate.

Roasted Asparagus

Roasted vegetables, especially asparagus, bring color and earthy flavor to balance the creamy pasta.

Herby Chicken Meatball Bowl

If you’re going full comfort mode, try a small side of the Herby Chicken Meatball Bowl for a protein-packed addition.

Caesar Salad

A crisp Caesar salad provides coolness and texture contrast to the hot, creamy dish.

Easy Homemade Naan Bread

Not traditional, but a warm slice of Easy Homemade Naan works beautifully for soaking up sauce.

Lemon-Infused Sparkling Water

To balance the spice, serve with a refreshing lemon sparkling water or light lemonade.

Roasted Zucchini and Squash

Pairing this dish with Roasted Zucchini and Squash adds a healthy, hearty veggie side to round out the meal.

Want More Chicken Pasta Ideas?

If you love this Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream, you’ll probably enjoy these other cozy and flavor-packed options:

• Creamy Tomato Spinach Pasta for a vegetarian-friendly classic with a velvety tomato base.
• Creamy Cajun Sausage Pasta when you want a bit more heat and smokiness.
• Garlic Butter Chicken Balls with Creamy Parmesan Pasta for a fun twist on traditional chicken dishes.
• Tuscan Chicken Pasta with sun-dried tomatoes and a Mediterranean flair.
• White Chicken Enchilada Casserole for a comforting bake with a similar creamy vibe.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you add mushrooms or swap the protein? Did you try a different cheese?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

Explore beautifully curated health-boosting drinks on Janet Dishes on Pinterest and discover your new go-to for feeling great!

Conclusion

This Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream brings cozy richness and bold spices into one unforgettable dinner. Whether you’re a pasta lover, a spice enthusiast, or someone just trying to get dinner on the table fast, this dish is sure to become a regular in your kitchen.

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