Creamy Cajun Steak & Cheddar Penne Skillet

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This creamy Cajun steak & cheddar penne skillet started off as a weeknight experiment, and oh wow, it turned into something completely crave-worthy. I was aiming for something comforting yet bold, and this skillet delivered every bit of that and more. I remember searing the steak and stirring the cheese into the sauce, and just knowing from the aroma alone it was going to be a repeat dish in my home.

What I absolutely love about this dish is how effortlessly it combines heat, richness, and texture. The Cajun seasoning adds that kick that makes your taste buds dance, while the melty cheddar blends into the sauce to create an irresistibly creamy finish. It all comes together in one skillet, which means less cleanup and more time to enjoy every bite. And let me tell you, there were zero leftovers that night!

When you want something hearty, cheesy, and a little spicy to brighten up your dinner routine, this recipe is your answer. It has the soul of Southern comfort food, the heartiness of a steak dinner, and the ease of a one-pan pasta.

Why You’ll Love This Creamy Cajun Steak & Cheddar Penne Skillet

This recipe hits every mark. It’s creamy, it’s spicy, and it’s packed with flavor. The steak brings a deep umami richness that balances beautifully with the sharp cheddar. The Cajun spices add excitement without overwhelming the dish. Best of all, it’s cooked in one skillet, making it perfect for busy nights when you want a comforting homemade meal without the fuss. Plus, if you love leftovers, this dish reheats like a dream—but only if you manage to have any left!

Ingredients

Steak: The star of the skillet, bringing hearty, meaty richness. I like using sirloin or ribeye for their tenderness and deep flavor.

Penne pasta: This pasta shape is ideal because its ridges hold onto the creamy Cajun sauce perfectly.

Cheddar cheese: Sharp cheddar melts into the sauce, giving it a creamy texture and a bold, tangy finish.

Heavy cream: The base of the sauce that turns everything silky and luscious.

Cajun seasoning: Adds boldness, heat, and that classic Southern flair. Make your own or use your favorite blend.

Butter & olive oil: Used to sear the steak and help develop a flavorful crust.

Garlic: Aromatic and savory, it deepens the flavor of the sauce.

Onion: Sautéed until soft, it adds natural sweetness and body.

Salt & pepper: Essential for seasoning each layer to taste.

Parsley (optional): A fresh garnish that brings brightness to the finished dish.

How to Make Creamy Cajun Steak & Cheddar Penne Skillet

Step 1: Sear the Steak

Heat olive oil and butter in a large skillet over medium-high heat. Season steak pieces with Cajun seasoning, salt, and pepper. Sear them in the skillet until browned and just cooked through. Remove and set aside.

Step 2: Sauté the Aromatics

In the same skillet, add a bit more butter if needed and sauté the chopped onion until soft. Add the minced garlic and cook for another minute until fragrant.

Step 3: Make the Creamy Cajun Sauce

Pour in the heavy cream, scraping up any bits from the pan for extra flavor. Stir in more Cajun seasoning and bring it to a gentle simmer. Reduce the heat and stir in the shredded cheddar cheese until it melts smoothly into the sauce.

Step 4: Cook the Pasta

Meanwhile, boil the penne pasta in salted water until al dente. Drain and add it to the skillet with the sauce.

Step 5: Combine Everything

Add the seared steak back into the skillet and gently toss everything together until well coated. Let it simmer for another 2-3 minutes so the flavors meld together.

Step 6: Serve and Garnish

Serve hot, garnished with fresh parsley if you like. Every bite is creamy, cheesy, and packed with Cajun-kissed steak goodness.

Recipe Variations and Possible Substitutions

You can absolutely make this dish your own. If you prefer chicken over steak, simply swap the protein. It works beautifully with chicken breast or thighs, seared and seasoned the same way. Want to go meatless? Try portobello mushrooms or even tofu for a hearty, vegetarian twist. You could also add bell peppers or spinach into the sauce for extra texture and nutrients.

If you don’t have heavy cream on hand, half-and-half or even whole milk with a touch of flour can create a similar creamy base. Swap the cheddar with pepper jack for a spicier kick, or use mozzarella if you want something milder and more melty.

Serving and Pairing Suggestions

This skillet dinner is rich and satisfying on its own, but you can elevate it further with a simple green salad dressed in lemon vinaigrette. A slice of warm, crusty bread on the side is perfect for soaking up the creamy Cajun sauce. I also love pairing this with a glass of chilled white wine or sparkling water with lime to balance out the richness.

For a family dinner, serve it directly from the skillet at the table. For meal prep, divide it into containers with a side of roasted vegetables for a full, comforting lunch.

Storage and Reheating Tips

Leftovers should be stored in an airtight container in the refrigerator for up to 3 days. To reheat, warm it on the stovetop over low heat, adding a splash of cream or milk to loosen the sauce. It also reheats well in the microwave—just be sure to stir halfway through to heat evenly.

This dish isn’t ideal for freezing due to the dairy content, which can separate. It’s best enjoyed fresh or within a few days.

FAQs

Can I make Creamy Cajun Steak & Cheddar Penne Skillet ahead of time?

Yes, you can prep everything ahead, including cooking the steak and pasta. Store them separately, then combine and reheat with the sauce just before serving.

What cut of steak is best for Creamy Cajun Steak & Cheddar Penne Skillet?

Sirloin is a great choice—tender, flavorful, and cooks quickly. Ribeye or NY strip also work well if you want something more indulgent.

Is Creamy Cajun Steak & Cheddar Penne Skillet very spicy?

The heat level depends on your Cajun seasoning. For a milder dish, use a low-sodium or mild blend, or reduce the amount.

Can I make Creamy Cajun Steak & Cheddar Penne Skillet gluten-free?

Absolutely! Just use your favorite gluten-free penne pasta and ensure your Cajun seasoning is gluten-free.

What cheese can I use instead of cheddar in Creamy Cajun Steak & Cheddar Penne Skillet?

You can substitute cheddar with Colby, Monterey Jack, or even gouda for a smoother, slightly sweet profile.

Related Recipe You’ll Like

If you loved this Creamy Cajun Steak & Cheddar Penne Skillet, then you absolutely have to check out my Creamy Cajun Shrimp Pasta next. It brings that same fiery Cajun flavor but swaps steak for juicy, plump shrimp, giving it a seafood twist that’s equally irresistible.

Another great dish to try is the Garlic Butter Steak Bites with Creamy Parmesan Shells. It’s a different take on steak and pasta with rich, cheesy goodness and bold garlic flavor.

And for a veggie-forward option, don’t miss the Roasted Zucchini and Squash Recipe – it pairs beautifully with this skillet dinner and adds a light, roasted contrast.

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If this Creamy Cajun Steak & Cheddar Penne Skillet made it to your list of must-try dinners, make sure to save it to your favorite recipe board on Pinterest. It’s a total crowd-pleaser for weeknight dinners, date nights, or special occasions when comfort food is the goal.

Don’t forget to share it with your friends and family! Pin it, email it, or drop the link in your favorite foodie group chat. Trust me, they’ll thank you later.

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